GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs1171113 | 1 | rs1171113 | chr6:84226595 | SNAP91 | chr6:84262607-84419127:- | -0.15 | -3.93 | 9.16E-5 | Bipolar disorder with mood-incongruent psychosis |
| BRCA | cis | rs1171113 | 1 | rs1171115 | chr6:84229623 | PRSS35 | chr6:84222274-84235419:+ | 0.14 | 4.01 | 6.61E-5 | Bipolar disorder with mood-incongruent psychosis |
| BRCA | cis | rs1171113 | 1 | rs1171115 | chr6:84229623 | SNAP91 | chr6:84262607-84419127:- | -0.13 | -3.41 | 0.000674 | Bipolar disorder with mood-incongruent psychosis |
| BRCA | cis | rs12638253 | 1 | rs11712111 | chr3:156608940 | LEKR1 | chr3:156544076-156763918:+ | 0.19 | 5 | 6.61E-7 | Multiple sclerosis (severity) |
| BRCA | cis | rs9876781 | 1 | rs11712561 | chr3:48435272 | ATRIP | chr3:48488141-48507708:+ | 0.1 | 3.45 | 0.000591 | Longevity |
| BRCA | cis | rs9876781 | 1 | rs11712561 | chr3:48435272 | TREX1 | chr3:48501186-48509043:+ | -0.28 | -10.62 | 4.27E-25 | Longevity |
| BRCA | cis | rs3796352 | 1 | rs11712653 | chr3:53070875 | NT5DC2 | chr3:52558386-52569093:- | 0.18 | 4.15 | 3.61E-5 | Immune reponse to smallpox (secreted IL-2) |
| BRCA | cis | rs4679904 | 1 | rs11713230 | chr3:160355942 | TRIM59 | chr3:160153292-160167626:- | 0.14 | 4.11 | 4.26E-5 | Primary biliary cirrhosis |
| BRCA | cis | rs3796352 | 1 | rs11713859 | chr3:53042080 | NT5DC2 | chr3:52558386-52569093:- | -0.21 | -4.33 | 1.61E-5 | Immune reponse to smallpox (secreted IL-2) |
| BRCA | cis | rs3796352 | 1 | rs11713859 | chr3:53042080 | RFT1 | chr3:53122503-53164470:- | 0.27 | 3.78 | 0.000167 | Immune reponse to smallpox (secreted IL-2) |
| BRCA | cis | rs3796352 | 1 | rs11713859 | chr3:53042080 | TMEM110 | chr3:52867139-52931547:- | 0.27 | 4.15 | 3.63E-5 | Immune reponse to smallpox (secreted IL-2) |
| BRCA | cis | rs3772130 | 1 | rs11714406 | chr3:121372513 | IQCB1 | chr3:121488610-121553926:- | 0.28 | 7.24 | 8.66E-13 | Cognitive performance |
| BRCA | cis | rs3772130 | 1 | rs11714406 | chr3:121372513 | SLC15A2 | chr3:121613171-121663034:+ | -0.13 | -3.83 | 0.000134 | Cognitive performance |
| BRCA | cis | rs3749237 | 1 | rs11717256 | chr3:49868520 | DALRD3 | chr3:49052435-49058467:- | 0.12 | 3.97 | 7.6E-5 | Resting heart rate |
| BRCA | cis | rs3749237 | 1 | rs11717256 | chr3:49868520 | P4HTM | chr3:49027341-49044579:+ | 0.08 | 3.4 | 0.000688 | Resting heart rate |